What is the reason for the high creatinine

Endogenous creatinine

Endogenous creatinine clearance is indicative of glomerular filtration. By the clearance, that is, the purification factor (ang. Clearance - purification) of any endogenous (intrinsic) or exogenous (extrinsic) of the substance to be understood that the amount of plasma - expressed in ml - which is the amount of the substance which is excreted in the urine in an time (second, minute).

Creatinine is the end product of protein metabolism intrasystemic (hence the name of the substance "endogenous"), its daily production in the system is constant (and dependent on age), the urinary excretion faithfully reflect the size of the "production". In healthy people, creatinine behaves in the kidneys, like inulin, ie. Is free glomerular filtration and during his trek through further, EXTRAGLOMERULAR part of the nephron is not absorbed or release in the renal tubules. Thus, in healthy individuals, in whom serum creatinine level is normal, creatinine clearance can be regarded as a sensitive indicator of glomerular filtration rate. However, at elevated serum creatinine content - which is one of biochemical signs of renal failure - is not only creatinine glomerular filtration rate, but also the renal tubular secretion, and this causes the clearance of this substance is significantly higher than the glomerular filtration rate. This discrepancy is even greater, the higher the concentration of creatinine in plasma, and thus the more severe the renal failure. This study thus allows for an approximate evaluation of filtration, and thus an approximate assessment of the degree of damage to the renal parenchyma.

What is the reason for the high creatinine?
 
1. The existing renal insufficiency people, such as infection, including colds, pneumonia, intestinal infections, urinary tract sense
Dyeing, elevated serum creatinine may occur in the short term.

2. The body dehydration, such as fever, sweating, reduce water consumption, resulting in blood concentration polyuria, renal blood
Flow reduction, elevated serum creatinine may occur.

3. The original kidney disease patients, the use of the drugs damage the kidneys, elevated serum creatinine may occur, or even irreversible.
   4. The original kidney disease patients, due to relapse, oliguria, and even anuria phenomenon, can be combined with acute renal insufficiency, leading to elevated serum creatinine.
   5. Life appeared tired, rest well, pay attention to the details of life, it can cause a transient increase in serum creatinine.
   6. The existing hypertension, uncontrolled blood pressure is good, long-term moderate and heavy proteinuria, elevated serum creatinine may slow progression unknowingly.
  The above points are the reasons for the high serum creatinine, serum creatinine must go to a regular hospital for routine examination