things related to iron metabolism of kidney disease

CKD Treatment

things related to iron metabolism of kidney disease
Over the last decade, people in the detection, understanding of iron metabolism in patients with CKD Treatment have made a lot of progress, these developments not only promote the rational use of EPO 141, reducing the dose of EPO (reduced by about 50%), but also improves the EPO effect. Research shows that the majority of CKD patients had varying degrees of iron deficiency, iron deficiency reserve and / or use of barriers hemoglobin iron deficiency or one of the main ESA generate reduced reactivity..

Functional iron deficiency" is more common manifestations of iron deficiency anemia in patients with CKD Treatment has two forms, namely "absolute deficiency" and "functional iron deficiency." Serum ferritin (SF) to reflect the status of iron stores, and transferrin saturation (TS) reflects circulating iron levels can be utilized. CKD generally recommended levels in hemodialysis patients for SF 200-500μg / L, TS levels of 30% -50% is appropriate, for reference. In recent years, some scholars believe that the reticulocyte hemoglobin content (reticulocyte hemoglobin content, CHr) and hypochromic red cell percentage (percentage of hypochromic red blood cells, PHRC,% HRC) may well reflect the state of the body's functions iron; but the domestic detection % HRC and CHr not generally experience less.

More effective ways iron Recent studies show that as a result of poor oral bioavailability of iron, so ESA therapy in hemodialysis patients to achieve target Hb targets (11-12g / dl), most of the required periodic intravenous iron. After intravenous iron after iron and transferrin-binding, can quickly supply the bone marrow; so not only can play a role in ESA's faster, and can reduce the dose of ESA (reduced by 30% -50%), thereby saving medical expenses. At present, the major clinical use intravenous iron sucrose iron (III iron hydroxide sucrose complex), iron dextran, gluconate, iron, etc., similar to the effect of its anemia, but with different iron incidence of adverse reactions vary with sucrose Rail safety