Experts had Iga nephropathy should tell you how to do

 IgA nephropathy

if you have the symptoms of edema, low back pain, abnormal urine and high blood pressure, you need to receive treatment going to hospital or you can send us email to igacure@gmail.com, we will give you some suggestions according to your individual condition. Except treatment, the details of your life you also need to notice, which are following.

1. Protein supply. You need to control your protein intake according to the damage level of your renal function. Because too much protein will increase the burden of your kidney.

2. Limit the salt intake. If you have serious edema and high blood pressure, you should keep low-salt diet, even salt-free diet.

3. Avoid medication toxicity to your kidneys. Almost all medicines have toxicity to kidney, so you should consult your doctor before you take them.

4. Get plenty of sleep. Most IgA nephropathy patients can feel fatigue, so you need to get plenty of sleep to remit fatigue.

5. Proper exercise. It is necessary to do some proper exercise, but strenuous exercise should be avoided.

6. Avoid stress to your immune system. You should know your immune system is not operating normally when you are diagnosed with IgA nephropathy. So it is necessary to avoid contacting the people with cough or cold even influenza.

What is the outlook for patients with IgA nephropathy?
Twenty to forty percent of the patients develop end stage kidney failure about 20 years after the disease becomes apparent. Patients who have an increased level of creatinine in their blood at the time of their diagnosis are more likely to develop chronic kidney failure. It is harder to predict which of the patients who have normal levels of creatinine at the time of diagnosis will develop kidney failure. In general, a poor prognosis is expected for those patients who have high blood pressure, high urine protein, and a significant amount of damage present in their biopsy specimen.

According to the investigation, there is no need for IgA Nephropathy patients to do special restrict on diet when their renal function is normal, but they should have low-salt and high-quality but low protein diet. When their renal function is reducing or insufficient, patients need to limit the intake of salt, protein and water. The following are the aspects needing attention on diet for IgA Nephropathy patients.

1. Limit salt and water intake. Patients with serious edema, high blood pressure and little urine, should have diet without salt. Daily water intake should be no more than 800 to 1200 liters and do not eat food rich in sodium such as pickles, vegetables pickled in soy sauce, salted eggs, preserved bean curd and tuber mustard. If edema subsidies, blood pressure drops and urine increases, patients can have a little salt about 2 to 3 grams.

2. Limit protein intake. If excessive protein has been taken, it would produce more nitrogen waste after metabolizing, which would increase the burden of kidneys. If urine is too little to discharge the waste, they will accumulate in the body, which would cause a series of poisoning symptoms. Therefore, patients should limit food rich in protein, such as meat, egg and bean product, etc. They can increase the intake of protein when getting better. But it does not mean you should avoid protein, because your body needs protein to function normally. Here lean meat, egg white and fish are recommended, because they are high quality protein, which has few waste.

3. Eat more food rich in vitamin, such as fresh vegetables and fruits which are alkaline food, so they can provide a variety of vitamins and promote the recovery of renal function.

Diet is important for IgA Nephropathy patients to control state of illness, but it should go with medication treatment. Only in this way can you achieve a good curative effect.

At last, please remember that IgA nephropathy is a chronic disease, so you need not to worry about “I have IgA nephropathy, what should I do”. The best thing for you is to keep active and positive attitude.

More information please Email to sjzkidneyhospital@hotmail.com about your problems and disease condition,we are glad to offer you more professional guidance for you as soon as possible for free.

IgAN is the world’s most common glomerulonephritis

In IgA Nephropathy

In IgA Nephropathy [IgAN], unknown agents cause the glomeruli to become — and to stay — inflamed. IgAN is the world’s most common glomerulonephritis [inflammation of the glomeruli], but its pathogenesis [how the disease develops] is not known. IgAN is considered to be an immune-complex mediated disorder (or immunologically mediated disorder), which means that immune complexes may not be the direct cause of the disease but they help bring about the end result, which is widespread inflammation of the kidneys.

Immune complexes form when the body is exposed to an antigen, such as a virus, bacteria, toxin, or even allergen. In response, your body sends out antibodies, which are immunoglobulins produced by a certain class of white blood cells known as B-cells. There are five main classes of these immunoglobulins, with IgA [immunoglobulin A] being the main one directed against bacterial and viral antigens.

Antibodies lock onto the surfaces of viruses and other foreign cells, producing antigen-antibody aggregates known as immune complexes that your body targets and attacks. Normally, these immune complexes circulate through the bloodstream until being removed by the liver and other organs. In IgAN, however, they become trapped in the glomeruli.

What are the signs and symptoms of IgA nephropathy?
The most common sign is blood in the urine. The amount of blood may be so small that it is only visible with the aid of a microscope. Another common sign is swelling of the feet.

As loss of kidney function progresses, symptoms may include pain in the back below the ribs, increased need to urinate (especially at night), fatigue, nausea, swelling of hands and feet and high blood pressure.

How is IgA nephropathy treated?
Efforts to slow the progression of kidney damage may include limiting the amount of protein in the diet and, if present, careful control of high blood pressure through diet and medication. If these treatments are not enough after a few months, then corticosteroids, such as prednisone, may also be considered. Fish oil has also been used as a treatment. Discuss the use of any supplement and medication with your doctor. For patients who develop progressive kidney failure, treatment may consist of dialysis or a kidney transplant.

The success rate of transplants is good in these patients. Even though the IgA deposits reappear in the transplanted kidney in about half the patients within one year after the operation, the signs and symptoms of the disease remain mild. Loss of a transplanted kidney to recurrent IgA nephropathy is uncommon. The milder form of the disease seen after transplantation may be due to the use of anti-rejection drugs such as cyclosporine.

What is the outlook for patients with IgA nephropathy?
Twenty to forty percent of the patients develop end stage kidney failure about 20 years after the disease becomes apparent. Patients who have an increased level of creatinine in their blood at the time of their diagnosis are more likely to develop chronic kidney failure. It is harder to predict which of the patients who have normal levels of creatinine at the time of diagnosis will develop kidney failure. In general, a poor prognosis is expected for those patients who have high blood pressure, high urine protein, and a significant amount of damage present in their biopsy specimen.

More information please Email to sjzkidneyhospital@hotmail.com about your problems and disease condition,we are glad to offer you more professional guidance for you as soon as possible for free.

IgA nephropathy daily dietary considerations

iga nephropathy

iga nephropathy diet is also true requirements. iga nephropathy patients when the disease is well controlled . urine normal . no edema and hypertension . iga nephropathy diet do not need to limit the salt intake . iga nephropathy salt nor will relapse , but do not advocate eating salty foods such as pickles. salted fish . bacon and other salted foods.

It should be noted that the iga nephropathy patients do not go to extremes : salt-free diet is unscientific long time will feel physical fatigue and dizziness .

Quality low -protein diet : is the egg lean meat and other dairy animal protein rich in essential amino acids , but their intake according to the condition may be normal renal function and urine protein should be given higher daily intake . .. 1 ~ 1.5g / kg * d. severely impaired renal function should be limited to a daily 0.6 ~ 0.8g / kg * d.

Specific iga nephropathy diet program may have about the two : A: Morning Noon milk 0.5 pounds of lean meat 1 egg white 2 two nights B:.... Early two egg whites for two nights at noon lean 2 egg whites 1 .

. Besides iga nephropathy following points need to diet as well as diet : 

1.iga kidney diet bogey : .. .. .. .. .. fishy spicy beef and mutton fried crab food seafood raw onions parsley garlic wine vinegar coffee spiced beef and mutton materials and all the big hair thing .

2.iga kidney diet bogey : .. .. .. animal offal millet seeds orange mushroom seaweed soy vegetable oil peanut banana prohibited ;

3.iga kidney diet bogey : . Lentil spinach lychee chocolate .

4. If iga nephropathy in patients with microscopic hematuria . Easy to get angry . No swelling may be more water . Eat apples . Sugar. Black sesame seeds. Fungus .

5.iga avoid high potassium foods kidney diet : .. .. potatoes, tomatoes, citrus soy sauce, MSG and other pumpkin tea in patients with low potassium consumption to the contrary .

Leave message on below or Email to sjzkidneyhospital@hotmail.com with your detailed disease condition,we are glad to offer you more professional guidance as soon as possible for free.

Make you a better understanding of IgA nephropathy

IgA nephropathy

Blood in the urine (hematuria) occurs in 10% of children on occasion. It may be microscopic, detected only with a dipstick or high magnification. It may be gross, with urine that looks like cola, red wine, or cherry Kool Aid. Sometimes kids have microscopic hematuria with intermittent episodes of gross blood. These children often have IgA nephropathy (IgAN).

There are a lot of different ways IgA Nephropathy can present. Here are some of them:

1. Asymptomatic hematuria: a lot of cases are picked up with routine urinalyses. Often these cases have little to no progression of renal disease over several decades.

2. Synpharyngitic hematuria: the "classic" presentation of IgA Nephropathy occurs within 1-3 days of a mucosal infection such as a URI.

3. Acute kidney injury: occasionally, IgA Nephropathy will first manifest as AKI. This can take 2 basic forms, and distinguishing between the two of them is critical:
A) The ATN Form: patients may become oliguric as a result of an acute worsening of hematuria, which can result in tubular toxicity, but will almost always recover renal full renal function afterwards.
B) The crescentic Form: patients with crescents on the background of mesangial IgA deposits on renal biopsy have a very poor prognosis and will often progress to permanent renal damage even despite aggressive therapy.

4. Nephrotic Syndrome: as mentioned above, IgA Nephropathy accounts for about 14% of all nephrotic syndrome in whites. This can also take two different forms:
A) "Minimal Change Disease" superimposed on IgA Nephropathy, which tends to be very steroid responsive.
B) "Structural Damage"--severe, prolonged damage to mesangial cells can result in secondary podocyte injury that is generally not reversible and can be thought of as a secondary nephrotic syndrome.

The course of IgAN varies from limited progression (or even some episodes of spontaneous remission) to rapidly progressive kidney failure. Kidney function measurements guide management:

Estimated glomerular filtration rate (eGFR)
Blood pressure (BP)
Protein:Creatinine ratio (P:C)
Nephrologists reserve biopsy, an invasive procedure, for children with abnormalities of at least one of these measures of kidney function, or children with multiple episodes of gross hematuria. Usually patients need no treatment if all measures of kidney function are normal, other than annual observation.

Leave message on below or Email to sjzkidneyhospital@hotmail.com with your detailed disease condition,we are glad to offer you more professional guidance as soon as possible for free.

iga nephropathy threat to children's health

iga nephropathy

IgA nephropathy (nuh-FROP-uh-thee), also known as Berger's disease, is a kidney disease that occurs when an antibody called immunoglobulin A (IgA) lodges in your kidneys. This results in local inflammation that, over time, may hamper your kidneys' ability to filter waste, excess water and electrolytes from your blood. Kidney damage may be indicated by blood and protein in your urine, high blood pressure and swollen feet.

IgA nephropathy usually progresses slowly over many years, but the course of the disease in each person is uncertain. Some people leak blood in their urine without developing problems, some eventually achieve complete remission, and others develop end-stage kidney failure.

No cure exists for IgA nephropathy, but certain medications can slow its course. Keeping your blood pressure under control and reducing your cholesterol levels also slow disease progression.

About 80% of children with IgA Nephropathy initiates the disease with hematuria which usually occurs after an Upper Respiratory Infection. Hematuria can exhibits in 24 to 72 hours after infection and this time hematuria can be seen by naked eyes (macroscopic hematuria). Some children are found tonsillar enlargement in this time; macroscopic hematuria may disappear after tonsillectomy.

Except above symptoms, children with IgA Nephropathy also can present Nephritis Syndrome (hematuria, massive proteinuria, edema and Hypertension). Hypertension usually signals exacerbation of the disease. However, only 5% of children are found of having Hypertension. Hypertension affects more adults with IgA Nephropathy than children. If people with IgA Nephropathy suffer from Hypertension, usually they have rapidly progressive kidney function deterioration. It is estimated that less than 5% of patients with IgA Nephropathy exhibit Rapidly Progressive Nephritic Syndrome.

IgA Nephropathy is a chronic kidney disease which can not be totally treated. But there are ways to control it well and to ensure the quality of life. The major treatment of IgA Nephropathy nowadays still relies on corticosteroids which can alleviate the symptoms quickly but may bring a lot of side effects to the patients. Therefore, patients with IgA Nephropathy should choose a safe and effective way to control the disease well.

Ask your doctor or Email to sjzkidneyhospital@hotmail.com with your disease report,we are glad to offer you more details directly as soon as possible.

iga nephropathy pathogenesis

IgA nephropathy 

IgA nephropathy commonly presents without symptoms through abnormal findings of protein excretion and presence of red blood cell on urinalysis. The diagnosis of IgA nephropathy can be made upon kidney biopsy, which is defined by the presence of immune deposits predominantly containing polymeric IgA in the glomerular mesangium. IgA nephropathy patients suffer no overt symptoms during the course of the disease until there is substantial loss of renal function has occurred and renal failure is imminent. For this reason IgA nephropathy was initially thought to be a benign disease, however it is now clear that there are not-so-benign long term outcomes for many patients.

Pathogenesis

A cause of IgA nephropathy is the mesangial deposition of underglycosylated polymeric IgA type 1 in IgA-containing immune complexes. Polymeric IgA1 is produced by cells of mucosal origin that are produced to antigens presented at different mucosal surfaces. Infections in the respiratory or gastrointestinal (GI) tract with a triggered mucosal immune reaction are commonly associated with IgA nephropathy, implicating these mucosal systems in the pathogenesis of the disease. Underglycosylated polymeric IgA1 is normally secreted by plasma cells, derived from antigen primed mucosal B cells, into the lumen of the gastrointestinal or respiratory systems as part of the immune defence of these tissues. However, there is evidence to suggest that in the case of IgA nephropathy patients, B cells primed at mucosal sites mis-home to the bone-marrow, and as plasma cell secrete underglycosylated polymeric IgA1 into the bloodstream. In the bloodstream, it is proposed that the polymeric IgA1 form complexes that are susceptible to autoimmune attack, which is turn results in very large complexes that deposit in the kidney mesangium triggering kidney inflammation. Prolonged kidney inflammation causes a cascade of events leading to scarring and fibrosis and subsequent loss of renal function. The intestinal mucosa is the greatest source of underglycosylated polymeric IgA1.

Risk of Progression

Patients with IgA nephropathy can be divided into two categories, those not at risk and those at risk of progressing to ESRD.

Patients not at risk of progressing to renal failure
- Sporadic episodes of macroscopic haematuria (blood in urine giving tea-coloured appearance) and possibly proteinuria (protein in urine) that may coincide with infections of the upper respiratory tract, or less often gastroenteritis.
- No treatment is required, although clinicians are recommended to observe the patient on a regular basis.

Patients at risk of progressing to renal failure
- Patients presenting with persistent proteinuria, which may be accompanied by hypertension and loss of renal function. These three factors are strongly associated with increased risk of progression to renal failure.
- Treatment is necessary.

What should IgA nephropathy patients pay attention to in diet?

What should IgA nephropathy patients pay attention to in diet?

What should IgA nephropathy patients pay attention to in diet?
What should patients with IgA Nephropathy pay attention to about their diet? It is a question many patients care about. Now, Funeng Kidney Disease Hospital will introduce what patients should pay attention to about their diet.

IgA Nephropathy is a kind of glomerulus disease which is caused by various reasons but has the same immunopathology characteristics. 40%-45% of the patients in clinic have gross hematuria and microscopic hematuria; 35%-40% have microscopic hematuria and urine protein; the rest have nephrotic syndrome and Kidney Failure. Therefore, patients with IgA Nephropathy should pay attention to their diet. They should do this from these aspects:
For the diet of patients with IgA Nephropathy, doctors often mention the high protein diet in the lessons. Patients with IgA Nephropathy should eat light liquid or semifluid food with high heat and high protein.

The study and clinical research indicate that IgA Nephropathy has relation to eating milk, cheese and soy protein, especially broad bean. Fresh broad bean can cause allergy and hemolysis. Therefore, patients with IgA Nephropathy should be restricted to eat this kind of food. Eliminating the glutelin in the diet can reduce the deposition of mesangial IgA and lower down the level of IgA complex. However, this method is difficult to apply to clinic in a long time, for its long-term meaning is not clear. So patients should pay attention to all the factors that have effect on their disease.

Patients with IgA Nephropathy should drink more water or beverage. Water is the source of life. (if there is no special case, for example, the doctor allow not to drink much water ) Drinking more water is an important aspect in patients’ diet, and their relatives can urge them to drink water.

Patients with IgA Nephropathy should not drink liquor. Drinking too much liquor can aggravate Hematuresis of patients, for the liquor contains alcohol which can stimulate mucosa and blood vessel and make the urinary organ have more serious inflammation. Meanwhile, mucosa hyperemia makes the red blood cells easy to leak, which form hematuresis.

Patients with IgA Nephropathy should not eat hot food. Restrict the stimulation of hot food to patients. Hot food such as garlic and hot pepper can stimulate urinary mucosa and make it have hyperaemia and edema. Meanwhile, the red blood cells are easy to leak, which form hematuresis.

Through the above introduction of the diet of patients with IgA Nephropathy, it is good for the patients’ recovery. If you have more questions about IgA Nephropathy, you can go to normal hospital to consult. Also, you can ask the on line experts for help, they will explain for you in time.