What is the reason for the high creatinine

Endogenous creatinine

Endogenous creatinine clearance is indicative of glomerular filtration. By the clearance, that is, the purification factor (ang. Clearance - purification) of any endogenous (intrinsic) or exogenous (extrinsic) of the substance to be understood that the amount of plasma - expressed in ml - which is the amount of the substance which is excreted in the urine in an time (second, minute).

Creatinine is the end product of protein metabolism intrasystemic (hence the name of the substance "endogenous"), its daily production in the system is constant (and dependent on age), the urinary excretion faithfully reflect the size of the "production". In healthy people, creatinine behaves in the kidneys, like inulin, ie. Is free glomerular filtration and during his trek through further, EXTRAGLOMERULAR part of the nephron is not absorbed or release in the renal tubules. Thus, in healthy individuals, in whom serum creatinine level is normal, creatinine clearance can be regarded as a sensitive indicator of glomerular filtration rate. However, at elevated serum creatinine content - which is one of biochemical signs of renal failure - is not only creatinine glomerular filtration rate, but also the renal tubular secretion, and this causes the clearance of this substance is significantly higher than the glomerular filtration rate. This discrepancy is even greater, the higher the concentration of creatinine in plasma, and thus the more severe the renal failure. This study thus allows for an approximate evaluation of filtration, and thus an approximate assessment of the degree of damage to the renal parenchyma.

What is the reason for the high creatinine?
 
1. The existing renal insufficiency people, such as infection, including colds, pneumonia, intestinal infections, urinary tract sense
Dyeing, elevated serum creatinine may occur in the short term.

2. The body dehydration, such as fever, sweating, reduce water consumption, resulting in blood concentration polyuria, renal blood
Flow reduction, elevated serum creatinine may occur.

3. The original kidney disease patients, the use of the drugs damage the kidneys, elevated serum creatinine may occur, or even irreversible.
   4. The original kidney disease patients, due to relapse, oliguria, and even anuria phenomenon, can be combined with acute renal insufficiency, leading to elevated serum creatinine.
   5. Life appeared tired, rest well, pay attention to the details of life, it can cause a transient increase in serum creatinine.
   6. The existing hypertension, uncontrolled blood pressure is good, long-term moderate and heavy proteinuria, elevated serum creatinine may slow progression unknowingly.
  The above points are the reasons for the high serum creatinine, serum creatinine must go to a regular hospital for routine examination

Shijiazhuang Kidney Disease Hospital Micro-Chinese Medicine penetration therapy

Shijiazhuang Kidney Disease Hospital

Shijiazhuang Kidney Disease Hospital research group showed: IgA nephropathy is different from other types of kidney disease, at any stage should actively seize early treatment, there is the possibility of reversal. Even if it is found from IgA nephropathy IgA nephropathy renal failure has become, as long as the active treatment, recovery of renal function is not impossible.

By blocking renal fibrosis theoretical explanation, is suffering from IgA nephropathy, mild renal impairment and normal renal function when started in time to avoid the occurrence of fibrosis, or fibrosis occurs early and fix them blocked, protect healthy after renal unit, to avoid further deterioration of the disease to renal insufficiency stage. The sooner the treatment of kidney disease, treatment is relatively easy, the greater hope for a cure.
First, to avoid the occurrence and development of fibrosis; secondly to control the progress of its rolling fibrosis, but control its progress is a long-term objective pathological repair process.

2, adhere to long-term: the long-term uninterrupted protect kidneys
Kidney disease is a chronic disease, so blocking renal fibrosis for disease treatment to be carried out, but also long-term adherence. From the start of treatment to protect kidney function block after blocking renal fibrosis impaired renal units to date from the date of repair, etc., until you reach the uremia has to do it.

3, the key root of the problem: Shijiazhuang Kidney Disease Hospital Micro-Chinese Medicine penetration therapy, blocking and renal fibrosis process, delaying the development of IgA nephropathy blocked.

Essence of chronic renal insufficiency is pathological changes of the kidney, the reason is kidney tissue fibrosis, destruction of healthy tissue renal units, and then damage the nephron function. Our hospital with Micro-Chinese Medicine penetration therapy, blocking renal fibrosis, delaying or blocking progress IgA nephropathy IgA nephropathy become kidney failure.

How to assist more effective treatment of IgA nephropathy

Note bed cultivation, should not stay up all night, fatigue, and strenuous exercise. Because IgA nephropathy is an autoimmune kidney disease, often influenced by a variety of adverse external factors. Therefore, care IgA nephropathy such situations, you need to be close observation and attention, to take timely measures to prevent, to prevent the development of disease.+
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What causes edema in ankles with IgA Nephropathy

IgA Nephropathy

"I am 54 years old. My blood pressure is 116/84. Creatinine is 1.54. Stage-3. Potassium-4.9mmol/l, Urea 71mg. Urine Protein 24-hours 128mg. I have edema in ankles and feet pain. Please tell me how can I cure this problem. Thank you!"
Proteinuria, edema in ankles, and pain in the foot are common symptoms of IgA Nephropathy. You said you were in the stage 3. This is the pivotal time for treatment. We must stop it develop into stage 4, if not, the condition will too serious.
What causes edema in ankles with IgA Nephropathy?
The disease is a kind of auto immune disease that occurs when too much IgA immune complexes deposited on the glomerular basement membrane, causing the proliferation and swelling of mesangial cells, thus damaging the charge barrier and mechanical barrier. The filtration membrane fails to block the leakage of proteins and red blood cells.
The massive loss of protein may lead to hypoproteinemia, leading to decreased plasma colloid osmotic pressure. So edema occurs.
In order to eliminate the symptoms of edema in ankles completely, we must remove the immune complex on the basement membrane and repair the damaged mesangial cells, the protein leakage will be stopped. Besides, we should restore the kidney function.
In our hospital, Immunotherapy and Micro-Chinese Medicine Osmotherapy are used together to treat IgA Nephropathy on the basis of exact diagnosis. We have to know what kind of immune complex is deposited and the amount and position it deposits exactly. In this way, we can give you targeted treatment. While controlling the immune reaction, Chinese medicine will be used for kidney repair and protection.
As one of the largest kidney disease specialized hospitals throughout the world, we have treated more than 20,000 patients with kidney diseases or Diabetes every year, and 30% patients suffer IgA Nephropathy. So, you can have the most successful chance of recovery.

Why have nephrotic syndrome

nephrotic syndrome

There are tiny blood vessels in the kidneys that filter waste and excess water from the blood stream. When these filters are damaged, a person will get Nephrotic Syndrome. The most common early symptom of this disorder, in both children and adults, is swelling in the tissues around the eyes or in the ankles or feet due to drop in osmotic pressure. The following gives detailed introduction.
Colloid Osmotic Pressure
 we need to do is to clean up the waste products stored within the body. Then, we should maintain the residual kidney function and repair the damaged renal cells so that your kidney function can be improved. In this way, your creatinine level will be lowered down and other symptoms will be eliminated.
It can also be referred to as oncotic pressure, which is a measurement of pressure exerted within the cardiovascular system by proteins found in blood plasma. Maintaining the proper levels osmotic pressure ensures that the body tissues maintain the proper levels of liquid and that too much liquid doesn't escape from the capillaries.
Normally, colloid osmotic pressure tends to cause fluid to be drawn into the capillaries. Variations in this pressure can lead to build up of fluid in the tissues, a condition called edema, or swelling.
Immunotherapy is a comprehensive therapy. The treatment process includes six steps like an accurate diagnosis (with our immune tests), immune blocking, immune clearance, immune tolerance, immune adjustment and immune protection. Specific steps may be adopted depending on personalized illness condition.
Swelling due to Drop of Osmotic Pressure in NS
Individuals with NS suffer from large quantity of Urine Protein. Massive proteins will get released into the urine, leading to reduced amount of plasma colloid osmotic pressure. If this happens, the normal exchange of body fluid is disturbed and cannot keep balance any more. Water in blood vessels will transfer toward tissue fluid, resulting in swelling.
Besides, another cause of edema in NS is also associated with low blood protein concentration.
Water in the blood transfers toward interstitial tissue, leading to low effective blood volume. This in turn gives rise to the production of Anti-diuretic Hormone (ADH). Renal tubules will reabsorb more water and sodium, resulting in more water retention. This condition will aggravate the swelling in NS.
The above is a general introduction of cause of swelling in NS. Is there still anything unclear about the disease? Contact our online doctor for free help.