Causes of Glomerulosclerosis

Kidney disease

Damaged glomeruli can't perform their job adequately. As a result, large amounts of protein from the blood leak into the urine rather than remaining in the bloodstream. This leads to a condition called proteinuria.

Causes of Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a kidney disease that can lead to glomerulosclerosis. In FSGS, the scarring occurs only in some of the glomeruli. And only part of the individual glomeruli is damaged.

Untreated, it can lead to kidney failure. In some cases, kidney failure can occur despite treatment.

FSGS most frequently occurs without a cause. In such cases it is called idiopathic or primary FSGS. Sometimes, though, FSGS does have a known cause, and these can include:

HIV infection
Obesity
Sickle cell disease
Birth defects of the kidneys
Heroin or other drug use
Genetic causes (in rare cases)
Besides FSGS, glomerulosclerosis can be caused by these diseases:

Diabetes
Lupus
HIV infection
Sickle cell disease
Conditions that damage the kidneys can also lead to glomerulosclerosis. These include:

Glomerulonephritis, which causes the glomeruli to become inflamed.
Reflux nephropathy, in which urine flows back into the kidney.
Chemicals and medicines that harm the kidneys can also cause glomerulosclerosis.

Symptoms of Glomerulosclerosis
At first, there are no obvious signs of glomerulosclerosis. Over time, symptoms can develop. These include:

Swelling. Because of fluid retention, you may have swelling in various parts of the body, including:

Hands
Feet
Legs
Abdomen
Around the eyes
The swelling may be painful. It may also cause rapid weight gain.

Changes in urine. You may have foamy or bubbly urine, caused by proteinuria.

Often, glomerulosclerosis is discovered during a routine checkup. Tests during a checkup can reveal an abnormally high protein content in the urine (proteinuria). Or they may show a low level of protein in the blood (hypoproteinemia).

Symptoms that often accompany glomerulosclerosis include:

High blood pressure
High cholesterol
In glomerulosclerosis patients, high blood pressure can be difficult to control.

Diagnosis of Glomerulosclerosis
The only way you can be certain of an accurate diagnosis of glomerulosclerosis is to get a kidney biopsy. That's because the symptoms of glomerulosclerosis can also occur in many other conditions.

In a kidney biopsy, your doctor removes a very small amount of kidney tissue. The tissue is examined for signs of scarring.

Diagnosing glomerulosclerosis may require multiple biopsies. That's because the scarring does not occur throughout the kidney. So your doctor may have to look at samples from several different parts of the kidney until an affected area is found.

And we also have many other unique therapies. We will adopt the best systemic therapy which is most suitable to the patient's kidney condition. If you need any help in curing your disease, you can leave messages or email to us. Our email: sjzkidneyhospital@hotmail.com