An autosomal recessive form of PKD Treatment also exists

PKD Treatment

An autosomal recessive form of PKD Treatment also exists
Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts in the kidneys. The kidneys are two organs, each about the size of a fist, located in the upper part of a person's abdomen, toward the back. The kidneys filter wastes and extra fluid from the blood to form urine.
Polycystic kidney disease (PKD) is passed down through families (inherited), usually as an autosomal dominant trait. If one parent carries the gene, the children have a 50% chance of developing the disorder.

Autosomal dominant PKD occurs in both children and adults, but it is much more common in adults. Symptoms often do not appear until middle age. The actual number may be more, because some people do not have symptoms.

Recent advances in the understanding of the genetic and molecular pathogenesis of both ADPKD and ARPKD have resulted in new, targeted therapies designed to disrupt cell signaling pathways responsible for the abnormal cell proliferation, dedifferentiation, apoptosis, and fluid secretion characteristic of the disease. Herein we review the current understanding of the pathophysiology of these conditions, as well as the current treatments derived from our understanding of the mechanisms of these diseases.

An autosomal recessive form of PKD Treatment also exists. It appears in infancy or childhood. This form is much less common than autosomal dominant PKS.
They also regulate amounts of certain vital substances in the body. When cysts form in the kidneys, they are filled with fluid. PKD Treatment cysts can profoundly enlarge the kidneys while replacing much of the normal structure, resulting in reduced kidney function and leading to kidney failure.


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